A total of 301 authors made valuable contributions to this field, out of which J.D. Featherstone had coauthored 6 articles. A significant negative correlation (p less then 0.01) was found between the age of the article and the citation density (r =-0.545). However, a nonsignificant correlation (p = 0.952) occurred between the age of publication and the citation count (r = 0.006). CONCLUSION ?The results of this systematic review provide a critical appraisal of the context underpinning scientific developments in the field of dental caries and also highlighted trends in clinical management and research.in English, German Beim ersten Einsatz eines LH-RH (heute GnRH)-Analogon zur Therapie des Prostatakarzinoms war das Kastrationsniveau von unter 50?ng/dl willkürlich festgelegt. Seither zeigen zahlreiche Untersuchungen, dass mit einer dauerhaften Senkung des Testosteronspiegels, wie z.?B. durch Buserelin, auf Werte von unter 20?ng/dl eine deutliche Verbesserung des Outcome einhergeht. Dies wird in aktuellen Studien belegt, sodass der Kastrationsspiegel mit Werten von unter 20?ng/dl zu fordern ist. Darüber hinaus stellt der Hormonentzug mit GnRH-Analoga weiterhin die Basistherapie für neue Therapieoptionen wie z.?B. mit Abirateron, Enzalutamid bzw. Apalutamid dar.BACKGROUND Unhealthy dietary habits and sedentary lifestyles have raised alarming concerns for the rising prevalence of metabolic syndrome (MetS) and associated cardiometabolic risk among Indians at an early age. Insulin resistance and adiposity are the important risk factors associated with MetS. The present study aimed to investigate the relationship between a modified marker of insulin resistance (homeostatic model assessment-adiponectin (HOMA-AD)) and cardiometabolic risk among middle-aged Indians. METHODS The study comprised of 144 subjects of age-group 31-50 years, where 83 subjects were diagnosed for MetS according to the guidelines given by the International Diabetes Federation. We measured cardiometabolic risk indicators such as fasting blood glucose (FPG), fasting plasma insulin (FPI), homeostatic model assessment- insulin resistance (HOMA-IR), adiponectin, high sensitivity C-reactive protein (hs-CRP), oxidized LDL (oxLDL), monocyte chemoattractant protein-1 (MCP-1), and atherogenic index, among others. We calculated HOMA-AD by the formula [FPG (mmol/l) × FPI (?IU/ml)] / [22.5 × Adiponectin (?g/ml)]. RESULTS HOMA-IR and HOMA-AD were highly increased (p less then 0.001) in the MetS subjects than controls. Adiponectin was significantly (p less then 0.01) lower whereas cardiac risk markers such as atherogenic index, hs-CRP, oxLDL, and MCP-1 were significantly (p less then 0.01) elevated in MetS group than controls. Linear regression showed positive and significant associations (p less then 0.01) of HOMA-AD with all the cardiometabolic risk markers except MCP-1. HOMA-AD showed higher AUC (0.806) than HOMA-IR (0.791) for predicting MetS. CONCLUSION HOMA-AD could be a surrogate adipokine-based marker correlated significantly with components of MetS and cardiometabolic risk indicators. It appeared to be a better predictor of MetS among middle-aged Indians than HOMA-IR. © Georg Thieme Verlag KG Stuttgart ? New York.What is music and how does it affect the human body? Historically, music is considered something divine because it has a huge impact on human emotions. https://www.selleckchem.com/products/gsk2193874.html This effect also has a psychosomatic effect and can influence and control the thoughts and actions of the listener. For example, purchasing behavior can be severely manipulated by musical accompaniment alone. Even the motivation can be either increased or reduced with the appropriate setting. In today's civilization, music accompanies people every day and is used for many different purposes. Thus, the musical stimulation is to be evaluated as a kind of psychotherapy, which is often used purposefully, but subconsciously takes place in the influenced. Of course, as there are still unanswered questions about the exact effect of music on the brain, many studies are currently being conducted in the field of neuroscience to fully understand this phenomenon.BACKGROUND The intestinal microbiota must be seen as an elementary component of our health. METHOD Review article RESULTS AND CONCLUSIONS An abnormal gut microbiota (dysbiosis) plays an essential role in the pathogenesis of functional and inflammatory bowel diseases. It is often also associated with diseases outside the intestine. The exact causality remains unclear ("chicken and egg problem"). With the help of prebiotics, probiotics or fecal microbiota therapy, relevant therapeutic effects can be achieved in chronic, dysbiosis-associated diseases. The choice of the preparation depends on the clinical symptoms, the duration of the treatment depends on the particular clinical picture.Nursing home residents and hospital patients are often relocated to other facilities or within their own facility in their last days of life. This means an additional burden for those affected and their relatives. In the Avenue-Pal project, the current transfer practice of dying persons is to be recorded and analyzed. Based on this data, care guidelines for hospitals and nursing homes are to be developed. The aims are to reduce the frequency of relocation, to increase the quality of care, to improve the satisfaction of those affected and their families, but also of the nursing staff, and last but not least, to save resources. The project is funded by the Innovation Fund of the Federal Joint Committee (G-BA).BACKGROUND Owing to the widespread use of vitamin supplements to prevent and compensate for deficiencies, the equivalence of natural versus synthetic vitamins with respect to their bioavailability and metabolic influence is discussed controversially. METHOD Thirty healthy female (n=22) and male participants (n=8) were investigated in a randomized, double-blind, cross-over study over a supplementation period of 6 weeks for each condition. The participants received a daily dose of a complex of the 8 natural B vitamins (group N), determined by the natural composition of quinoa seedlings, resp. synthetic B vitamins (group S), both corresponding to about 2.5 times the Recommended Dietary Allowance (RDA) of the national nutrition board. The primary criterion under investigation was changes in the blood levels of the individual B vitamins. Secondary criteria were the influence of both B complexes on homocysteine, antioxidant status, polyphenols, peroxide loading and peroxidase activity. RESULTS Compared to baseline values, serum levels of all B vitamins measured increased Vitamins B1 (N +23%; S +27%), B2 (N +14%; S +13%), B6 (N +101%; S +101%), B9 (N +86%; S +153%) and B12 (N +16%) were elevated at the end of the first supplementation period (p less then 0.